“This success has enabled the rapid development of highly effective vaccines against Covid-19. In addition to providing a tool to limit the spread of the devastating epidemic, innovation supports progress toward treating and preventing a variety of diseases.”
Their technology has been licensed to BioNTech, a partner in Pfizer’s vaccine production company, and to Moderna, whose vaccine was developed in part with US federal research funding.
“The global influence and recognition of Wiseman and Carrick’s work has its roots in years of joint research at the University of Pennsylvania to explore RNA as a potential therapy,” the University of Pennsylvania statement said.
Their groundbreaking study, published in 2005, found that their concept—which brought new hope to a region blighted by doubts and false starts—could be a reality: mRNA can be altered and then effectively introduced into the body to initiate a protective immune response. Their method is to turn cells into factories that can temporarily produce proteins that act as therapeutic compounds or stimulate the body’s immune system to attack specific pathogens that also reduce harmful inflammatory responses. “
The foundation said using RNA is a safe way to make vaccines. “Unlike DNA, mRNA does not compromise the genetic integrity of the recipient cell because it cannot integrate into the chromosome and disrupt resident genes or cause other mutational damage,” she added.
This technology allows labs to produce vaccines very quickly — they should be faster than older technologies — and helped Pfizer and Moderna begin producing vaccines on the day the new coronavirus was sequenced in January 2020.
Carrico and Wiseman will share $250,000.
“Sometimes we would ask questions and do an experiment,” said Cariko. “And of course, instead of answering, we got 100 more questions. It was a lot of fun. I like to stress that being a scientist is fun.” So.
Previous Lasker Prize winners are Jonas Salk, who developed the polio vaccine, and Dr. William Voig, who helped remove smallpox and former director of the US Centers for Disease Control and Prevention, and Dr. Anthony Fauci, director of the National Polio Institute. Allergies and infectious diseases. Dozens of Lasker Prize winners have won Nobel Prizes.
Dr. David Baltimore, a Nobel Prize-winning researcher at Caltech for his help discovering reverse transcriptase – which some viruses use to copy their genetic material – also beat Lasker on Friday.
Pallitmore, founding director of the Whitehead Institute for Biomedical Research at MIT, is one of the world’s leading HIV/AIDS researchers. Received the Lasker-Koshland Prize for outstanding achievement in the medical sciences.
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